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- 17.06.2020
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In , the first in-human clinical trial was initiated; which used human ES cell-derived materials to treat spinal cord injury. Shinya Yamanaka at Kyoto University successfully reprogrammed adult fibroblasts common cells in connective tissue that form the extracellular matrix and collagen to revert back into an embryonic-like pluripotent state—simply by expressing four specific genes. A year later, human iPS cells were made in a similar fashion by both Thomson and Yamanaka.
Yamanaka later received the Nobel Prize some argue that Thomson deserved to share the prize. Photo credit: rf stock photos. The ability to reprogram adult cells back into a pluripotent state suggested we could create an unlimited supply of pluripotent cells that genetically matched a specific individual—without the ethical baggage of using human embryos. Of course, this is easier said than done. The technical difficulties and high cost of generating and editing iPS cells from individual patients have complicated the development of iPS-based treatments.
Currently, there is only one human clinical trial using cells derived from iPS cells, which treats macular degeneration an incurable eye disease that leads to blindness. Despite the emergence of iPS cells, ES cells have continued to dominate in the clinical realm. The future is bright, but there is still one major problem in ES cell-based therapies. But no fear, scientists have a plan. David Russell mentioned in the beginning of this blog re-engineered human embryonic stem cells to remove specific proteins—human leukocyte antigens HLA —from the cell surface.
Removing HLA proteins is like wrapping the foreign cell with an invisible cloak, rendering it unnoticeable by the immune system. Only one cell line is needed, which reduces the cost, complexity and time required for clinical trials. Russell and many others believe that UDCs are the future of regenerative medicine. In fact, UDC-based therapies to treat cancer, macular degeneration, skin wounds and type 1 diabetes are already being developed. It is amazing to see how far we have come over the last 20 years.
Thanks to visionary scientists like James Thomson, Shinya Yamanaka, David Russell—and countless other principal investigators, post-docs and grad students who work tirelessly in the lab every day—treatments for many life-threatening diseases may be available in the near future. Students participate in the lab at the Celebration of Life Camp. Students present what they learned at the Celebration of Life Camp to families and friends. This program took place from June 27th- July 1st and provided an introduction to DNA and how biotechnology can be applied to better understand how genes are used by cells.
Activities took place in the BTC Institute labs and were designed by certified educators. These experiences are geared towards middle, high school, and college students accompanied by their teachers. Students apply hands-on techniques to immerse themselves in various biotechnology concepts with the help of instructors and a fully equipped molecular biology laboratory.
Recently, on July 8th, the BTC Institute hosted a customized field trip for MAYDM : A local Madison organization that provides girls and youth of color, grades , with skill-based training for the technology sector. This field trip focused on exploring how bioluminescence can be used for drug discovery.
Students toured cell line labs, participated in an experiment in the BTC Institute labs, and learned from scientists and the DEI program manager through a panel discussion. Maydm students learning how bioluminescence is used for drug discovery in the BTC Institute lab. Dane County Youth Apprenticeship Program in Biotechnology In addition to summer experiences, the BTC Institute also offers various apprenticeship programs and courses for students during the academic year.
This program offers paid training in an industry or UW-Madison research lab. Students may elect a two-year apprenticeship or a one-year senior internship for high school credit hours required per year. Additionally, students participate in a weekly specialized biotechnology course during the academic year at the BTC Institute.
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